http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S61189297-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0931241d9441d023245580a92141bf68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate | 1985-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afedfac682cc62a0a880b0490432541d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07c50ab48ecd7c6bcb517b91c5d06108 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39927f744859ff318b50a1798b624ac6 |
| publicationDate | 1986-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S61189297-A |
| titleOfInvention | Proline derivative |
| abstract | NEW MATERIAL:The compound of formula I (R1 is 5-14C alkyl, 2-6C alkenyl, etc.; R2 is H or 1-6C alkyl; R3 is 1-6C alkyl; R4 is H, phenyl 1-6C alkyl, etc.; n is 0, 1 or 2) and its salt. EXAMPLE:N-[(R)-1-ethoxycarbonyl-2-hexylthioethyl]-alanyl-(S)-proline beta-isomer. USE:A hypotensor, an immunoactivating agent, a remedy for glaucoma, etc. It has excellent angiotensinase inhibiting activity, rapid activity, long duration time, an low toxicity. PREPARATION:The objective compound can be produced e.g. by reacting the cysteine derivative of formula II with the alpha-keto acid in the presence of a metal hydride complex compound such as lithium borohydride, and reacting the resultant carboxylic acid of formula IV with the amine of formula V in the presence of a condensation agent such as N,N'-dicyclohexylcarbodiimide in a solvent such as THF, at -10 deg.C - room temperature for 3-24hr. |
| priorityDate | 1985-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.