| abstract |
PURPOSE: To obtain the titled preparation stable at room temperature, injectable as an aqueous solution, by adding a substance selected from a thiol compound, a high polymer compound and a water-soluble salt of deoxycholic acid to a prostaglandin E, and lyophilizing the blend. n CONSTITUTION: A prostaglandin E is blended with a substance selected from a thiol compound (e.g., gluthathione, cysteine, etc.), a high polymer compound (e.g., dextran, dextrin, PVP, etc.), and a water-soluble salt of deoxycholic acid and an alkali metal, arginine, or lysine) in an amount not to show medicinal effect, and lyophilized. Preferably an amount of the thiol compound per vial is 1W20mg, an amount of the high polymer compound is 5W250mg, and an amount of the water-soluble salt of deoxycholic acid is 5W100mg. The PGE having wide pharmaceutical action such as contraction of the womb, hypotensive action, remedying and preventing action on ulcer of digestive organs, vasodilating action, etc., can be preserved stably at room temperature for a long period. n COPYRIGHT: (C)1986,JPO&Japio |