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filingDate 1984-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1986-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S61159169-A
titleOfInvention Immunological reagent for diagnosis
abstract PURPOSE:To discriminate easily the presence of absence of agglutination and to make possible a reagent for diagnosis having an excellent shelf life by compounding sulfolane with a water dispersion of water dispersion type high- molecular polymer particles immobilized with an immunologically active material so as to co-exist therein. CONSTITUTION:The water dispersion type high-molecular polymer particles are dispersed into a buffer soln. such as glycine buffer soln., phosphoric acid buffer soln. or boric acid buffer soln. having suitable pH and concn. so as to prevent the inactivation of the immobilized immunologically active material and the sulfolane is compounded as awn additive for suppressing the non-specific agglutination of the particles with the water dispersion of such polymer particles. Since the non-specific agglutination of the polymer particles is thoroughly prevented, the quick discrimination is possible without the dilution of serum with a buffer soln. or without inactivation treatment. The reagent for diagnosis is easy to mix uniformly with the serum. The discrimination of the presence or absence is thus made easy and the shelf life thereof is remarkably improved.
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