http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S61158962-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1374dd16777534b65ad4422333245af8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C201-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90 |
| filingDate | 1985-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7980bac3cc1c51f46c2de219993286b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fa60d88d2ba55246568e9dbbf7a4d6a |
| publicationDate | 1986-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S61158962-A |
| titleOfInvention | Production of 1,4-dihydropyridine derivative |
| abstract | PURPOSE: To obtain the titled compound having pharmaceutical actions such as blood flow increasing action, vasodilating action,antihypertensive action, etc. by a simple operation in high yield, by reacting a novel α-benzyl-β-keto-ester derivative with an enaminocarboxylic acid derivative. n CONSTITUTION: A β-keto-ester derivative is reacted with a corresponding ben zaldehyde compound in the presence of a halide to give a novel α-benzyl-β-keto- ester derivative shown by the formula I (R 1 and R 2 are H, halogen, nitro, or CF 3 ; with the proviso that R 1 =R 2 ≠H, and R 3 and R 4 are lower alkyl; X is halogen) easily in high yield. This compound is reacted with an enamino carboxylic acid derivative shown by the formula II [R 6 is as shown for R 3 and R 4 ; R 5 is R 6 , or (substituted)aralkyl; n is 1W3] preferably in a solvent at 30W120°C optionally in the presence of a base for 30minW24hr, and, then option ally subjected to a salt formation reaction, to give the aimed compound shown by the formula III to be expected as an improved agent for circulatory organs or its nonpoisonous salt. n COPYRIGHT: (C)1986,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012142815-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011201790-A |
| priorityDate | 1985-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.