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filingDate 1984-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_237c27731d12a24ccd11fe696526a1f1
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publicationDate 1986-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S61148174-A
titleOfInvention 1-benzoxepin-2-one derivative and preparation thereof
abstract NEW MATERIAL:The 1-benzoxepin-2-one derivative of formula I (R is H, 1W3C alkoxy or halogen). n EXAMPLE: 5-Phenyl-2-oxo-2,3,4,5-tetrahydro-1-benzoxepine. n USE: Useful as a synthetic intermediate of various medicinal drugs having cerebral function improving action and active to circulatory system, central nervous system, digestive system, etc. For example, a diallylbutyric acid derivative exhibiting the above activities at a low dose and also having the lipid peroxide suppressing effect, can be synthesized by dissolving the compound of formula I in a solvent, adding excess N-methylpiperazine to the solution and heating and refluxing the mixture. n PREPARATION: The compound of formula I can be prepared by reacting γ- phenyl-γ-butyrolactone with the phenol derivative of formula II in the presence of a base, and subjecting the resultant compound of formula III to the coordination and dehydrative cyclization under acidic condition. n COPYRIGHT: (C)1986,JPO&Japio
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type http://data.epo.org/linked-data/def/patent/Publication

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