| abstract |
NEW MATERIAL:(+)-(2R*,3R*)-3-(2-aminophenylthio)-2-hydrox-y-3-(4-met-hoxy- phenyl)propionic acid ester of formula I (R is 1W4C lower alkyl). n USE: An intermediate of diltiazem hydrochloride useful as a coronary vasodilator. n PREPARATION: The compound of formula I can be prepared by reacting (-)-(2 R*,3R*)-2,3-epoxy-3-(4-methoxyphenyl)propi-onic acid ester of formula II with 2-aminothiophenol in a solvent (e.g. toluene) at 100W140°C. n COPYRIGHT: (C)1986,JPO&Japio |