| abstract |
NEW MATERIAL:A compound of formula I [A is single bond, methylene, ethyl ene, vinylene; B is 4W8-membered hydrocarbon ring which may be substituted with O, N, S; T is O, S; R 1 is formula II (R 5 , R 6 are H, halogen), alkyl; R 2 is H, 1W6C alkyl; R 3 is H, halogen, hydroxyl; when B forms a ring, R 4 is the formula: -U-(CH 2 ) n -COOR 8 (U is O, S; R 8 is H, 1W6C alkyl; n is 0, 1W10)], and its non-toxic salts. n EXAMPLE: 7-(p-Hexyloxybenzoyl)amino-2-(r-tetrazolyl)benzofuran. n USE: Leucotriene antagonist, phospholipase inhibitor. n PREPARATION: A carboxylic acid of formula III or its corresponding dithionic acid is allowed to react with an amine of formula IV to form an amide bond, when needed, saponified to give a compound of formula I. n COPYRIGHT: (C)1986,JPO&Japio |