| abstract |
NEW MATERIAL:The compound of formula I [R 1 is halogen, NO 2 , NH 2 , OH, alkyl, alkoxy, etc.; R 2 is H or halogen; X is O or NR 3 (R 3 is H, alkyl or acyl); A is group of formula II or formula III (R 4 is H, alkenyl, alkynyl or alkyl): or R 1 is H or alkoxy; R 2 is H; X is R 3 a (R 3 a is alkanoyl); A is group of formula IV] and its salt. n EXAMPLE: 8-Chloro-4,5-dihydro-1-methyl-5-propionyl-1H-pyrazolo[4,-3-C]quinoline. n USE: A drug having diuretic, uricosuric and vasodilating activities. n PREPARATION: The objective compound of formula I can be prepared by reacting the compound of formula V [B is OH or NR 5 R 6 (R 5 and R 6 are alkyl)] or its salt with the compound of formula R 4 NHNH 2 . The compound of formula V is novel, and is prepared by the reaction of the compound of formula VI with the compound of formula VII (R 7 and R 8 are alkyl) or an alkyl formate. n COPYRIGHT: (C)1986,JPO&Japio |