http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S61112015-A

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filingDate 1985-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ed78c3209e3363aaf4ce5d84b47841f
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publicationDate 1986-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S61112015-A
titleOfInvention Pharmaceutical preparation
abstract PURPOSE: To provide a pharmaceutical preparation for transcutaneous absorption and capable of releasing isosorbid dinitrate (a medicine of stenocardia) slowly at a constant rate for a long period, by applying an adhesive base layer containing the drug to the surface of a polyester film and coating the base layer with a polymer layer through which the drug can be migrated. n CONSTITUTION: A surface of a polyester film having a thickness of preferably 6W9μm is coated with a base layer containing 1W25wt% isosorbide dinitrate (ISDN) effective for the suppression and prevention of the fit of stenocardia. In the above preparation, the adhesive surface of the base layer is coated with a polymer such as an ethylene-vinyl acetate copolymer having a vinyl acetate content of preferably 22W40wt% to control the ISDN content in the base layer and prevent the crystallization of ISDN. A pharmaceutical preparation having excellent adhesivity to the skin and moderate drug solubility and drug releasability, and free from the problems such as stimulation or staining of the skin, can be prepared by this process. n COPYRIGHT: (C)1986,JPO&Japio
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H02142434-U
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6471907-A
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0754259-Y2
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priorityDate 1985-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 31.