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filingDate 1984-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1986-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S61109736-A
titleOfInvention Drug for external use
abstract PURPOSE: To provide a drug for external use, having improved releasability of the principal drug without causing the decomposition of the drug, and useful for the surgical treatment and prevention of various infectious diseases, by adding negamycin or its salt as an active component to a gelatinous base, and adding cyclodextrin to the mixture. n CONSTITUTION: Negamycin (abbreviated as NGM) or its salt and cyclodextrin are added to a gelatinous base. NGM is effective for the remedy of various infectious diseases (e.g. impetigo, folliculitis, sycosis vulgaris, superficial pyoderma, etc.) caused by Gram-positive bacteria and Gram-negative bacteria represented by Pseudomonas aeruginosa, and its resistant strain, however, it has the problems of stability in the base and the releasability from the base when used as an external drug. It has been found that the concentration of NGM can be increased rapidly to the bactericidal level and the decomposition of the principal drug can be prevented by using the agent in combination with cyclodextrin and a gelatinous base (e.g. carboxyvinyl polymer). Since a gelatinous base is used in the present drug, it is free from fat and oil, suitable even to seborrheic diseases, and fixed firmly to the mucosa and damaged moist part. n COPYRIGHT: (C)1986,JPO&Japio
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S62292719-A
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