| abstract |
NEW MATERIAL:A compound shown by the formula I {one of R 1 and R 2 are is H, and the other is hydroxy, or amino, or R 1 and R 2 are linked to form formula = N.NHR 4 [R 4 is benzoyl, p-toluenesulfonyl, or group shown by the formula II (R 3 is H, hydroxy, or lower alkanoyloxy)]}. n EXAMPLE: 7-(2-Dimethylaminoethyl)amino-9-(1-hydroxy)ethyl-6,9,11-trihydroxy-7,8, 9,10-tetrahydroxynaphthacene-5,12-dine. n USE: A carcinostatic agent. Administrable orally or parenterally, 0.1W100mg is administered daily per adult once W several times dividedly. n PREPARATION: A compound shown by the formula III is reacted with a boron reducing agent (e.g., sodium cyanoborohydride) in a mixed solvent of water, methanol, etc., at -20W40°C, to give a compound shown by the formula I. n COPYRIGHT: (C)1986,JPO&Japio |