http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S61100580-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dfd617dc43a4c986d2dd81e4cb39d9dd |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-56 |
| filingDate | 1984-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad16b6e2b9add15ddd484c5f5c541f20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b33df4fe209375635c776b281d01377b |
| publicationDate | 1986-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S61100580-A |
| titleOfInvention | Indazole derivative |
| abstract | NEW MATERIAL:An indazole derivative of formula I [R<1> is H, formula III (R<5> is cyano, carboxyl, lower alkoxycarbonyl), formula IV (R<2>, R<3> are H, lower alkyl, or they incorporate to form alkylene; R<4> is R<5>); n is 1-3] and its salt. EXAMPLE:3-(1-Imidazolylmethyl)indazole hydrochloride. USE:It has an action to inhibit the synthesis of thromboxane A2 and is used to prevent or treat stenocardia, isthemic cardiopathy, cerebarovascular diseases and thrombosis. PREPARATION:As shown in reaction equations, a compound of formula II [X is halogen; R<11> is H, formula V (R<41> is cyano, lower alkoxycarbonyl)] is allowed to react with 1-acetylimidazole in a solvent such as acetonitrile at room temperature to the boiling point of the solvent to give a compound of formula Ia, which is hydrolyzed to give a compound of formula Ib. |
| priorityDate | 1984-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.