| abstract |
NEW MATERIAL:The compound of formula I [R 1 is lower alkyl; R 2 is H or CH 3 ; k is integer of 0W3; m is 0 or 1; X an Y are H or CH 3 ; A is H, group of formula II (R 3 and R 4 are lower alkyl or together form a ring) or group of formula III (n is 2 or 3; R 5 is lower alkyl)] and its acid addition salt. n USE: Remedy for digestive tract disorder and remedy for schizophrenia, depression, etc. n PREPARATION: The compound of formula I can be produced by reacting the compound of formula IV [R 6 is OH, halogen, -O-R 7 or -O-COO-R 8 (R 7 and R 8 are lower alkyl)] with the compound of formula V in the presence of a condensation agent (e.g. N,N'-dicyclohexylcarbodiimide) in an inert organic solvent (e.g. acetone, chloroform, etc.) at a temperature between -10°C and the refluxing temperature (preferably at room temperature). The compound of formula IV is also novel. n COPYRIGHT: (C)1985,JPO&Japio |