http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6061533-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cef2a6d661df17e57ad3155c24188735 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46 |
| filingDate | 1983-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7618018ae7b551c0c49de707e211d7b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40cbef1e5b9b909188cbfc9c6aad9b02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63e8c33b6a55b116a8130d6370ad68b9 |
| publicationDate | 1985-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S6061533-A |
| titleOfInvention | Modified urokinase |
| abstract | PURPOSE: Modified urokinase obtained by bonding chemically a fraction having affinity for fibrin prepared by hydrolyzing human plasminogen to urokinase. n CONSTITUTION: Human plasminogen [prepared by linkage product of (H chain peptide)-(L chain peptide) from the side of N end] is hydrolyzed with a proteolytic enzyme (e.g., elastase of swine pancreas), and a fraction having affinity for fibrin(linkage product of K 1 -K 2 -K 3 having 27,000W39,000mol.wt.) is obtained from the hydrolyzed mixture by fractionation and collection through affinity chromatography using an adsorbent obtained by bonding ligand to lysine and gel filtration. This fraction is chemically bonded to urokinase, to give modified urokinase having high adsorption porperty of fibrin. In the chemical bonding, a crosslinking agent by ionic mechanism such as condensation reaction, addition reaction, etc. is used. It is suitable as a thrombolytic drug. n COPYRIGHT: (C)1985,JPO&Japio |
| priorityDate | 1983-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.