| abstract |
PURPOSE: The titled preparation that is produced by dispersing lipid microcapsules which are formed by mixing an aqueous solution or suspension with a phospholipid containing a lipophilic surfactant, at least one of which contains the medicament, in a dispersion medium, thus being increased in the medicament content with high stability. n CONSTITUTION: An aqueous solution or suspension and a phospholipid such as phosphatidyl choline containing a lipophilic surfactant such as polyoxyethylene sorbitol monooleate, at least one of which contains the medicament, are mixed with stirring and the resultant microcapsules are dispersed in a dispersion medium such as polyoxyethylene glycol to give the objective lipid microcapsule preparation containing medicament. When it is oily, the preparation can be formed into a solid one by freeze- or spray-drying. The resultant preparation can control the elution speed of the medicament and transferrence to tissues and can raise the content of the medicament higher than in the liposome preparations. Further, its stability is higher than W/O/W type complex emulsion. n COPYRIGHT: (C)1985,JPO&Japio |