| abstract |
NEW MATERIAL:A compound shown by the formula I [R 1 is H, or (protected) OH; R 2 and R 3 are (protected)OH; R 4 is (protected)aldehyde]. n EXAMPLE: 2',4'-Di-O-acetyl-3-O-t-butyldimethylsilyl-23-deoxy-23-oxo mycaminosyl tylonolide diethyl acetal shown by the formula II. n USE: An antibacterial agent, and an intermediate for preparing mycaminosyl tylonolide. n PREPARATION: A compound shown by the formula III (R 5 is protected OH; R 6 is protected aldehyde; with the proviso that R 5 and R 6 are the same group as that of protected OH and aldehyde) is reacted with pyridinium-trifluoroacetate and N,N-dicylohexyl carbodiimide usually in a mixed solvent of anhydrous dimethyl sulfoxide and anhydrous benzene at room temperature, and the protecting group is eliminated. n COPYRIGHT: (C)1985,JPO&Japio |