http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6048966-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b9036c33bbe3f4ea428655b76200f7c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 |
| filingDate | 1983-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e738e06f9117be727fdd82ebec2a11d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2105648d9bc5e500a780851fda78e555 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2f9745f328edc5db8c9e538c9bc2389 |
| publicationDate | 1985-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S6048966-A |
| titleOfInvention | Preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1- propanol |
| abstract | PURPOSE: To obtain the titled compound useful as a new drug suitable as a remedy for sequelae of cerebrovascular disease efficiently, by hydrogenating a specific novel compound in the presence of a resonable hydrogenating catalyst under mild conditions, optionally reacting the reaction product with an acid. n CONSTITUTION: A 4-benzyl-1-[1-( 4-benzyloxyloxyphenylcarbonyl )ethyl]pyridinium halide shown by the formula I (X is halogen; Bel is benzyl) is reduced with a metal hydride such as NaBH 4 , etc. in a solvent at -40W70°C for 30minW10hr to give novel 1-(4-benzyloxyphenyl)-2-(4-benzyl-1,2,5,6-tetrahydropyridino)-1-propanol shown by the formula II in high yield. This compound is hydrogenated in a solvent in the presence of hydrogenating catalyst such as 10wt% Pd/C, etc. at normal temperature under normal pressure, and, if necessary, the reaction product is reacted with an acid, to give the desired compound shown by the formula III. n COPYRIGHT: (C)1985,JPO&Japio |
| priorityDate | 1983-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.