http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6045596-A

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filingDate 1983-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ca3e928ea8a2b3484432d22d3762461
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publicationDate 1985-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S6045596-A
titleOfInvention Production of dipeptide
abstract PURPOSE: To produce a dipeptide, in high efficiency, in the peptide synthesis with thermolysin using N-substituted phenylalanine or N-substituted aspartic acid and a phenylalanine lower alkyl ester as the substrate, by using the substrate in the form of a specific emulsion. n CONSTITUTION: A dipeptide is produced by reacting an N-substituted phenyl- alanine or an N-substituted aspartic acid with a phenylalanine lower alkyl ester (hereinafter called as Ph-ester). The reaction is carried out by contacting immobilized thermolysin with an O/W type emulsion having a volume ratio (aqueous phase/organic phase) of 1:1 and obtained either by dispersing a mixture of an N-substituted phenylalanine and a water-immiscible organic solvent in water containing Ph-ester, or by dispersing a water-immiscible organic solvent in water containing N-substituted aspartic acid and Ph-ester. n USE: Synthetic reaction reagent of peptide having physiological activity or a precursor of synthetic sweetener. n COPYRIGHT: (C)1985,JPO&Japio
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priorityDate 1983-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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