| abstract |
NEW MATERIAL:The compound of formula I (R is 16W18C straight-chain alkyl). n EXAMPLE: 1-0-Hexadecyl-2,3-di-0-acetyl-D-threitol-4-phosphorylcholine. n USE: Hypotensor, blood platelet coagulant, and their intermediate. n PREPARATION: The compound of formula I can be prepared by (1) reducing the compound of formula II with palladium black usually in glacial acetic acid at room temperature for 1W10hr to obtain a dihydroxylated compound, and (2) acetylating the product with e.g. acetic anhydride usually in an organic solvent, if necessary in the presence of a base (e.g. pyridine, triethylamine, etc.). n COPYRIGHT: (C)1985,JPO&Japio |