http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6038396-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb4ee28d43b5e8d4a3c5141fa9bcfeb0 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-067 |
| filingDate | 1983-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf1d827e8c8b0b63559643e4eefd000b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_059ff566cecae01da5f02778ab95def5 |
| publicationDate | 1985-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S6038396-A |
| titleOfInvention | Preparation of 5-fluorocytidine compound |
| abstract | PURPOSE: To obtain the titled compound useful as a carcinostatic agent and antiviral agent in high yield efficiently, by reacting a cytidine compound with fluorinating agent in a mixed solvent containing hydrogen fluoride and a carboxylic acid, etc. to give an intermediate, reacting it with ammonia, etc. n CONSTITUTION: A cytidine compound shown by the formula I (R 1 WR 4 are H, or lower acyl) is reacted with a fluorinating agent (e.g., F 2 , CF 3 OF, etc., usually diluted in an inert gas such as N 2 to 50mol% and used) in a mixed solvent of (A) hydrogen fluoride and (B) a carboxylic acid shown by the formula R 5 OH [R 5 is (halogenated)lower acyl, or halogenated lower alkyl] or a halogenated alcohol (preferably acetic acid, or trifluoroacetic acid) (preferably 5W80wt% component A, ≤500ppm water content) to give a 5-fluorocytidine intermediate shown by the formula II. This compound is reacted with ammonia or an amine, to give the desired compound by the formula III. n COPYRIGHT: (C)1985,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7365188-B2 |
| priorityDate | 1983-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.