http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6028980-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7478ccf6996666c3d6ed739dc2d5ec7d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D323-00 |
| filingDate | 1983-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b651b29f8af0b23a4a0e205870f2cf32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a52018822d61a093352ea8a4185fce68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9eaef035563127ce35c1c1396c2a098 |
| publicationDate | 1985-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S6028980-A |
| titleOfInvention | Crowned thebaine |
| abstract | NEW MATERIAL:The compound of formula I (Me is methyl). n USE: For the preparation of opiate having the property of opiate as well as that of ionophore, and having improved activity by preventing the change in the steric structure of the opiate receptor with sodium ion. n PREPARATION: The compound of formula I can be prepared e.g. by (1) reacting thebaine of formula II with iron pentacarbonyl, (2) treating the obtained thebaine iron complex with boron tribromide, etc. to obtain a phenolic compound, (3) reacting the compound with tetraethylene glycol monotosylate in the presence of sodium hydride, etc., (4) tosylating after the treatment with p-toluenesulfonic acid, (5) reducibly opening the ether ring with zinc and acetic acid, etc., and (6) cyclizing the resultant phenolic compound of formula III (Ts is tosyl) with sodium hydride, etc. and treating with trimethylamine oxide, etc. n COPYRIGHT: (C)1985,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H06295770-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S62201220-U |
| priorityDate | 1983-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.