| abstract |
NEW MATERIAL:The compound of formula I [R 1 is H or carboxyl-protecting group; R 2 is (substituted) aryl; R 3 is halogen or (substituted) cyclic amino] and its salt. n EXAMPLE: 7-Chloro-6-fluoro-1,4-dihydro-1-( 4-methoxyphenyl )-4-oxo-3-quinolinecarboxylic acid. n USE: An antibacterial agent exhibiting strong antibacterial activity against Gram- positive and Gram-negative bacteria, especially to the bacteria resistant to antibiotic substances, keeping high concentration in blood by oral or parenteral administration, and having high safety. n PREPARATION: The compound of formula I or its salt can be prepared by cyclizing the compound of formula II (R 3a is halogen) or its salt in the presence or absence of a base, and if necessary, reacting the product with the compound of formula R 3b -H [R 3b is (substituted) cyclic amino]. n COPYRIGHT: (C)1985,JPO&Japio |