http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S60222496-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eea080e03bbd9386a81a90c22aa8bf43 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J51-00 |
| filingDate | 1984-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0e8aeca64aef36694cd29e4760de040 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa0f786a6c2b6c2f23907f73fb8bae55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa636d60c41d1e14feb94ef4bc3c5175 |
| publicationDate | 1985-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S60222496-A |
| titleOfInvention | Steroid derivative having aldosterone antagonism |
| abstract | NEW MATERIAL:A compound shown by the formula I (X is hydroxy, Y is alkali metallic salt of carboxyethyl, or X and Y together with neighboring carbon atom form lactone ring shown by the formula II). n EXAMPLE: 17-Hydroxy-6β-,7β-methylene-3-oxo-17α-pregna-1, 4, 11-triene-21-carboxylic acid.γ-lactone. n USE: A hypotensive diuretic. Useful for remedying hypertension, renal edema, etc. n PREPARATION: 3-17-Bis(ethylene dioxide)-androsta-5,11-diene as a starting raw material is deketalized, reacted with a secondary amine to give enamine shown by the formula III, which is processed into a compound shown by the formula IV, to give a halohydrin shown by the formula V. The compound shown by the formula V is processed into an allyl alcohol derivative, and converted into a silyl ether. Then, β-methylene group is introduced to the compound shown by the formula VI, the prepared silyl ether is processed into a hydroxyl compound, and oxidized, to give the desired substance. n COPYRIGHT: (C)1985,JPO&Japio |
| priorityDate | 1984-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.