| abstract |
PURPOSE: To prepare the titled preparation minimizing the oxidative decomposition reaction of the drug and the substrate material, by compounding a substrate containing a drug for transcutaneous absorption with powdery polymer having phenolic hydroxyl group. n CONSTITUTION: A substrate containing a drug for transcutaneous absorption (e.g. corticosteroid, analgesic and anti-inflammatory agent, hypnotic sedative, tranquillizer, hypotensive drug, anesthetic, etc.) is compounded with 2×10 -4 W2wt%, preferably 5×10 -4 W5×10 -1 wt% powdery polymer having phenolic hydroxyl group [e.g. the compound of formula (X is OH, methyl, methoxy, etc.; R is H or t-butyl) and having a molecular weight of about 1,000W9,000]. The obtained drug for external use is preferably used in the form of ointment, suppository, poultice, liniment, lotion or tape. A tape is one of extremely desirable drug forms from the viewpoint of the improvement in the effective utility of the drug and the simplicity of application. n COPYRIGHT: (C)1985,JPO&Japio |