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filingDate 1984-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca6648beecaac5ac516ba9cd88d83eae
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publicationDate 1985-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S60197638-A
titleOfInvention Preparation of optically-active mevalonic ester
abstract PURPOSE: To obtain simply the titled compound useful as an intermediate for synthesizing various optically-active organic compounds, by reacting inexpensively obtainable optically-active mevalonolactone and its derivative as a raw material with a lower alkyl alcohol in the presence of a basic catalyst. n CONSTITUTION: An optically-active mevalonolactone shown by the formula I (R is H, or OH-protecting group) obtained by microbial oxidation of 3-methyl-pentane-1,3,5-triol and its derivative [e.g., optically-active (S)-mevanonolactone, etc.] is reacted with a lower alkyl alcohol shown by the formula R'OH (R' is 1W5C lower alkyl) in the presence of a basic catalyst (preferably basic ion exchange resin or ammonia) to obtain an optically-active mevalonic ester derivative [e.g., (S)-mevalonic acid methyl ester, etc.] shown by the formula II. Unreacted mevalonolactone or its derivative is reusable for esterification reaction. n COPYRIGHT: (C)1985,JPO&Japio
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