| abstract |
NEW MATERIAL:The compound of formula I [R<1> is H or lower alkyl; R<2> is H or halogen; X is 1-15C alkylene or vinylene; Y is carbonyl or group of formula II(R<3> and R<4> are same as R<1>); Z is H, 1-15C alkyl or cycloalkyl; the sum of the C number of X and Z is >=3]. EXAMPLE:1-(3,4-Dihydroxyphenyl)-4-methyl-3-octanol. USE:Pharmaceutical and its intermediate. It has extremely strong activity to block or suppress the production and release of SRS-A, and is useful for the prevention and remedy of various allergic diseases, ischemic diseases, inflammation, etc. caused by SRS-A. PREPARATION:The compound of formula I can be prepared e.g. by reducing or hydrolyzing the corresponding 1-(3,4-disubstituted phenyl)alkane of formula III(R' is OH-protecting group; X' is 1-15C alkylene; R<1>' is OH-protecting group or lower alkyl; Y' is group of formula II wherein R<3> may be OH-protecting group). |