http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S60169485-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a77d66ff67a9626dd7de5cce2097afcd http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d75d1a4caed60a9316608ed9c231546c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-08 |
| filingDate | 1984-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aca105564e8f974c9005ea7016b2892f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae36e9e5ee14cf7b21b9b12375acef87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a32d88911d911ade6dbcf67b34fd0c0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe6e6d91344d8b95a76a5f074f0a73de |
| publicationDate | 1985-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S60169485-A |
| titleOfInvention | Preparation of antibiotic substance a23187 methyl ester |
| abstract | PURPOSE: To obtain the titled compound useful for an antifungal agent from an easily available raw material, by protecting the hydroxyl group of a specific dioxaspiro compound, deacylating the resultant compound, oxidizing the deacylated compound, forming a pyrrolyl compound therefrom, deprotecting the pyrrolyl compound, oxidizing the deprotected compound, reacting the oxidation product with an aminophenol, and cyclizing the resultant reaction product. n CONSTITUTION: A benzoyldioxaspiro compound expressed by formula I is reacted with tert-butyldiphenylsilyl chloride, and the resultant compound is debenzoylated, treated with an oxidizing agent and reacted with dipyridyl disulfide to afford a compound expressed by formula II (But is tert-butyl group), which is then reacted with an N-pyrrolylmagnesium salt to give a compound expressed by formula III. the resultant compound expressed by formula III is then desilylated and treated with an oxidizing agent and reacted with a chloroformic acid ester and an aminophenol expressed by formula IV, dehydrated, cyclized and deacylated to afford the aimed compound expressed by formula V. n COPYRIGHT: (C)1985,JPO&Japio |
| priorityDate | 1984-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.