http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S60166650-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24aca9ded2638ea793d05360dde7a4a0 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C313-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-76 |
| filingDate | 1984-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f04f930a45fea5bbcd50a90d532704bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7092184ee3f9ba85a5518635be287551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0008ccb2abac12bf8b350ca246384b9a |
| publicationDate | 1985-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S60166650-A |
| titleOfInvention | Preparation of acylamino-naphthalene derivative |
| abstract | PURPOSE: To obtain the titled compound useful as a carcinostatic agent and a synthetic intermediate therefor in high yield, by reacting a racemic or optically active amino-ester derivative with a methylsulfinyl carbonion, desulfurizing the reaction product, and acylating the desulfurized product. n CONSTITUTION: A racemic or optically active amino-ester derivative of formula I (R is ester residue) is reacted with a methylsulfinyl carbonion in a solvent at -10W+60°C to give a sulfoxide derivative of formula II, which is then reduced with zinc dust, and desulfurized with aluminum amalgam, etc. to afford an amino-ketone derivative of formula III. The resultant compound of formula IIIis then acylated in the presence of an organic base by the conventional method to give the aimed substance of formula IV. The racemic amino-ester derivative is if necessary optically resolved with one of mandelic acid, tartaric acid, dibenzoyltastaric acid, camphorsulfonic acid and 3-bromo-camphorsulfonic acid for use. n COPYRIGHT: (C)1985,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016041687-A |
| priorityDate | 1984-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.