| abstract |
PURPOSE: To raise permeability and percutaneous absorption of physiological activator, by using a multi-component carrier system consisting of at least one adjuvant (component A) and at least one solvent (component B). n CONSTITUTION: The component A of at least one (10W26C aliphatic monoalcohol and its mixture) is blended with the component B of at least one [thioglycerol, lactic acid or its ester, cyclic urea, compound shown by the formula I (R 1-4 are H, 1W4C lower alkyl, or 1W2C acyl), compound shown by the formula II (R 5 is H, or 1W4C lower alkyl; n is 3W5), compound shown by the formula III (R 6 is H, 1W3C alkyl; R 7 and R 8 are 1W3C alkyl; with the proviso that total number of carbons of R 6 , R 7 , and R 8 is at least ≥3], the blend is mixed with a physiological activator, and applied to the skin. An amount of the component A to be used is 0.1W80wt% based on total amounts of the components A and B. Benzodiazepine, etc. may be cited as the activator, and its amount is 0.01W50wt% based on the total amounts. n COPYRIGHT: (C)1985,JPO&Japio |