http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S60130581-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1374dd16777534b65ad4422333245af8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-32 |
| filingDate | 1983-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f67982bde3d5f809f99a870890a3dc7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c25440c1c5dd4b2cc880a922187f5f52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6576e2785f80ae0855620bb32a298632 |
| publicationDate | 1985-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S60130581-A |
| titleOfInvention | Production of 1alpha,25-dihydroxyvitamin d3-26,23-lactone |
| abstract | PURPOSE: To produce the titled compound useful for the remedy of hypercalcemia, etc., economically, by irradiating a novel 1α.3β.25-trihydroxycholesta-5.7- diene-26.23-lactone with ultraviolet radiation, thermally isomerizing the product, and if necessary, removing the protecting group. n CONSTITUTION: A novel 1α.3β.25-trihydroxycholesta-5.7-diene-26.23-lactone of formula I (R 1 and R 2 are H or protecting group) is irradiated with ultraviolet rays of about 200W360nm wavelength, especially 260W310nm wavelength to effect the cleavage of the 9-10 bond and obtain a 1α.25-dihydroxyprevitamin D 3 - 26.23-lactone. The product is thermally isomerized at 20W120°C, preferably 40W 100°C, and if the product has an OH-protecting group, the protecting group is removed by conventional method to obtain the objective compound of formula IIeconomically in an industrial scale in high yield. The novel substance of formula I can be produced from the compound of formula III via the intermediates such as the compound of formula IV (R 3 is OH-protecting group), etc. n COPYRIGHT: (C)1985,JPO&Japio |
| priorityDate | 1983-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.