| abstract |
PURPOSE: To obtain the titled compound by one stage efficiently, by using an active halogen-containing compound and a phase transfer catalyst, reacting an aromatic nitro compound with a metal fluoride in a specific solvent so that NO 2 group of aromatic nucleous a replaced with F effectively. n CONSTITUTION: An aromatic nitro compound shown by the formula I (X and Y are Cl, Br, F, or H; with the proviso that X=Y≠; R 1 WR 3 are Cl, Br, F, or NO 2 , CN, CF 3 or H) is fluorinated with a metal fluoride such as preferably KF, etc. in an aprotic polar solvent such as especially preferably sulfolane, etc. in the presence of an active halogen-containing compound shown by the formula II (Z is Cl, Br, or F; n is 1W3), formula III, etc. and a phase transfer catalyst shown by the formula IV (A 1 WA 3 are alkyl, aryl or combination of them, B is Cl or Br) or formula V at 100W200°C at 1W5kg/cm 2 pressure for 1W30hr, to give the desired compound shown by the formula IV R 4 WR 6 are as shown for R 1 WR 4 ). n COPYRIGHT: (C)1985,JPO&Japio |