| abstract |
NEW MATERIAL:A compound shown by the formula I [R 1 is H, or lower alkanoyl; R 2 is aryl, aralkyl, or 4-W7-membered monofunctional heterocylic group containing 1W4 hetero atoms such as nitrogen, oxygen, sulfur, etc., or group shown by the formula-R 3 -Y-R 4 (R 3 is lower alkylene, etc.; R 4 is alkyl, aryl, cycloalkyl, aralkyl, heterocyclic group, etc.; Y is O, S, or direct bond of R 3 and R 4 , etc.)]. n EXAMPLE: 4"-(3-Pyridyl)acetyltylosin. n USE: An antimicrobial agent microorganisms having resistance to tylosin. n PREPARATION: For example, tylosin shown by the formula II is reacted with a reactive derivative of acetic acid, so that hydroxyl group at 2' position is selectively acetylated, and the resultant compound is reacted with a reactive derivative of an acid shown by the formula R 2 COOH, to give a compound shown by the formula I . n COPYRIGHT: (C)1985,JPO&Japio |