| abstract |
PURPOSE: The titled inclusion compound useful as vitamin A, D, E, or K as a drug, having stability to heat, light rays, and oxidation, and water solubility, obtained by reacting a fat-soluble vitamin with cyclic (1→2)-β-D-glucan. n CONSTITUTION: 1W100wt% aqueous solution of cyclic(1→2)-β-D-glucan having 17W24 polymerization degree is reacted directly with a fat-soluble vitamin such as vitamin A, D, E or K, or a solution of it in a small amount of an organic solvent with stirring for 4W48hr. Then the reaction solution is allowed to stand for 1W24hr, only the water layer of lower layer is taken out, dried by through flow drying, drying under reduced pressure, etc., to give fat-soluble vitamin- cyclic(1→2)-β-D-glucan inclusion compound powder. n EFFECT: Useful as a solid drug such as tablet, capsule, granule, powder, etc. and injection. n COPYRIGHT: (C)1985,JPO&Japio |