| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_39ae96c0ecc22ff90ff986371a3cea0f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-738
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C201-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-455 |
| filingDate |
1984-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa4c63dc3e98abcca8ade201807c6fcc |
| publicationDate |
1985-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-S601154-A |
| titleOfInvention |
Intermediate of 1,4-dihydropyridine derivative |
| abstract |
NEW MATERIAL:The compound of formula I [R 1 is aryl or heterocyclic group which may have proper substituent group; R 3 is esterified carboxy; R 5a is H, alkyl or oxy-substituted alkyl (the formed carbonyl is protected with a proper protecting group)]. n EXAMPLE: 2-(2-Chlorobenzylidene)-4,4-diethoxyacetoacetic acid ethyl ester. n USE: A synthetic intermediate of the 1,4-dihydropyridine derivative of formula IIhaving vasodilating and hypotensive activities and useful as a drug. n PREPARATION: The objective compound of formula I can be prepared by reacting the aldehyde of formula R 1 -CHO with the β-keto acid ester of formula R 5a - COCH 2 -R 3 . The compound of formula II is obtained by the reaction of the compound of formula I with the compound of formula III (R 2 is same as R 3 ; R 4a is same as R 5a ). n COPYRIGHT: (C)1985,JPO&Japio |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0223968-U
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0616661-Y2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-10010377-B4 |
| priorityDate |
1975-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |