| abstract |
PURPOSE:The titled composition, containing an extract of a beehive of long-legged wasps, wasps or hornets or Vespula lewisi Lameron, and useful for preventing and treating gingivitis. CONSTITUTION:A composition for the oral cavity containing an extract of a beehive of long-legged wasps, or hornets of Vespula lewisi Lameron. The inflammation of gingivitis is supposed to be caused by action of oral bacteria in the sordes on teeth, i.e. action of collagenase, protease, hyaluronidase, etc. derived from bacteria on the periodontal tissues or local cause of action of amines, endotoxins etc. derived from bacteria or systemic causes such as nutritional conditions or diabetes, etc. The composition containing the extract of the beehive exhibits particularly effective action on reduction and suppression of periodontal inflammations. Water or an organic solvent, e.g. methanol or ethanol, is used as a solvent for extracting the beehive. The amount of the extract to be incorporated is preferably 0.001-10wt% based on the total composition, and particularly preferably 0.01-5wt% from the viewpoint of anti-inflammatory effect and feeling of use. |