| abstract |
NEW MATERIAL:The compound of formula I (R 1 is H, hydroxy or lower alkoxy; R 2 is H, lower alkanoyl or trifluoroacetyl). n EXAMPLE: 4-Demethoxy-14-acetamidodaunomycin. n USE: A synthetic intermediate for an anthracycline derivative useful as a carcinostatic agent. n PREPARATION: The compound of formula I can be produced by reacting the halogen compound of formula II(X is halogen) with the amide of formula R 3 CONH 2 (R 3 is lower alkyl or trifluoromethyl) in the presence of silver fluoride or cesium fluoride in a solvent such as dimethylformamide, preferably in the presence of a base (e.g. triethylamine) at 0W40°C, and hydrolyzing the resultant amide compound. n COPYRIGHT: (C)1985,JPO&Japio |