| abstract |
NEW MATERIAL:A compound of formula I [R 1 is 8W22C alkyl, phenyl-substituted 2W5C alkyl; R 2 is azido, amino, etc.; R 3 is 1W8C alkylene; R 4 is amino, -NHCOR 6 (R 6 is 1W4C alkyl), -NHR 6 , -N(R 6 ) 2 , etc.] and an acid addition salt thereof. n EXAMPLE: (2RS)-1-O-Hexadecyl-2-dehydroxy-2-azido-3-O-[4-(dimethylamino)butyl] glycerol. n USE: Useful as a blood platelet agglutination inhibitor, antiasthmatic agent, antiallergic agent, anti-inflammatory agent, hypotensive agent and antitumor agent. n PROCESS: A compound of formula II (R 7 is alkylsulfonyl, etc.; R 4a is a group of -NHCOR 6 , etc.) is reacted with sodium azide in a solvent, e.g. hexamethylphosporamide, at room temperature W80°C to give the aimed compound of formula I (R 2 is amino; R 4 is R 4a ). n COPYRIGHT: (C)1984,JPO&Japio |