| abstract |
NEW MATERIAL:A compound shown by the formula I [R is H, or ethyl; group A is -CH 2 -CH 2 -, -CH 2 -CH 2 -CH 2 -, group shown by the formula II, etc.; n is 0, or 1) and its acid addition salt. n EXAMPLE: Flavone-8-carboxylic acid.2-(piperidin-1-yl)ethyl ester.hydrochloride. n USE: Useful as a remedy for disorders of urinary tract such as remedy of pollakisuria, etc. Having action like papaverine, inhibitory action on micturition reflex, contracting action on urinary bladder, etc. n PROCESS: A flavone-8-carboxylic acid halogenide derivative shown by the formula III(x is halogen) is reacted with an amino-alcohol derivative shown by the formula IV in an organic solvent such as acetone, etc. at room temperature-under reflux by heating, to give a compound shown by the formula I . n COPYRIGHT: (C)1984,JPO&Japio |