http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S597172-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5dfc0b033ac4c841466d97a5f28ea32b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 |
| filingDate | 1982-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d32c27e3b813858670fc7e5bd4479d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f3293ef9853f8715f5e2a4d604f7dfa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c47f13f9b3ff3856d1cfaba20baa47e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff434e2b0ea120426bd26593aaa336a5 |
| publicationDate | 1984-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S597172-A |
| titleOfInvention | Preparation of guanidine derivative |
| abstract | PURPOSE: To prepare N-cyano-N'-methyl-N"-{ 2-[ ( 5-methylimidazol-4-yl )-methylthio]ethyl}guanidine by reacting quaternary ammonium salt of 4-methylimidazole with corresponding mercaptan. n CONSTITUTION: The compound of formula I can be prepared by (1) reacting the compound of formula VI with the compound of formula III (R 1 and R 2 are lower alkyl, lower alkenyl, aralkyl or together with N form a heterocyclic group) and HCHO at 50W100°C to obtain the tertiary amine of formula IV, (2) reacting the amine with the alkylation agent of formula V (R 3 is lower alkyl, lower alkenyl or aralkyl; Q is acid residue), and (3) reacting the resultant quaternary ammonium salt of formula II with a mercaptan of formula VII in a lower alcohol solvent such as methanol. n EFFECT: The compound can be obtained by one-pot reaction under mild condition, and accordingly, the yield is high. n USE: Remedy for ulcer. n COPYRIGHT: (C)1984,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022034121-A1 |
| priorityDate | 1982-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.