| abstract |
NEW MATERIAL:The phenylpiperazine derivative of formula I (R 1 is lower alkyl; R 2 , R 3 and R 4 are H, halogen, lower alkyl, lower alkoxy, OH, trifluoro- methyl, lower alkoxycarbonyl, or adjacent two groups of R 2 , R 3 and R 4 together form methylenedioxy group; n is 2W6), and its salt. n EXAMPLE: 1-(2-Methoxyphenyl)-4-(2-benzoylaminoethyl)piperazine. n USE: It has hypotensive activity, cerebral blood flow increasing activity, and the activities to decrease the pulse rate and suppress the ventricular arrhythmia caused by myocardial ischemia, and is useful as a remedy for circulatory diseases. n PROCESS: The compound of formula I can be prepared, e.g. by reacting the compound of formula II with the compound of formula III in an inert solvent such as benzene, toluene, etc. in the presence of a catalyst comprising a base such as sodium carbonate, triethylamine, etc. under heating and stirring. n COPYRIGHT: (C)1984,JPO&Japio |