http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5953498-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_204ea9f0f83d1c51a916e46a41a6a14a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-234 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-236 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-234 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7028 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7034 |
| filingDate | 1982-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92b5dbdbb2968008aeb158620c8ee760 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cc8c532f23ec9a96265116bf431ba70 |
| publicationDate | 1984-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5953498-A |
| titleOfInvention | 5,2',3',4',4",6"-hexadeoxykanamycin and its 1-n-acryl derivative |
| abstract | NEW MATERIAL:A compound (acid addition salt) shown by the formula I [A is H, or (S)-4-amino-2-hydroxybutyryl]. n EXAMPLE: 5,2',3',4',4",6"-Tetradeoxykanamycin. n USE: A chemotherapeutic agent. A chemotherapeutic agent especially effective for various kinds of resistant bacteria. n PROCESS: Four amino groups of a 3',4'-dideoxykanamycin shown by the formula II(R is H) are protected with amino-protecting groupa, this compound is treated with a base such as sodium hydroxide, etc. in an anhydrous aqueous solution, to give a compound shown by the formula III (R is amino-protecting group; R 1 and R 2 are OH). Hydroxyl groups at 2', 4", and 6" positions of this compound are sulfonated and thiophenylated, and hydrolyzed to give a deoxy compound shown by the formula III wherein R 1 is H. Hydroxyl group at 5 position of this compound is converted into S-methylthiocarbonyl group, and successively hydrolyzed, to give a 5-deoxy compound, and two amino-protecting groups are eliminated. n COPYRIGHT: (C)1984,JPO&Japio |
| priorityDate | 1982-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.