http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5946242-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d3de607e369a55daf2120ea4267a4827 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-612 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-30 |
| filingDate | 1982-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bd21d969859339e8f97932311a38e12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_220a2adfb8f9dee91cc6c1532fe5f94d |
| publicationDate | 1984-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5946242-A |
| titleOfInvention | Preparation of propionic acid having aromatic group at alpha-position and its ester |
| abstract | PURPOSE: To prepare the titled substance useful as an intermediate of pharmaceuticals, etc., economically, at a low cost, with safe operation without using toxic materials, by reacting an acetic acid ester having an aromatic group at the α-position with a methylating agent in the presence of an aqueous solution of caustic alkali and a quaternary ammonium salt. n CONSTITUTION: The objective compound can be prepared by the methylation reaction of the acetic acid ester of formula (R 1 is H or inert substituent group such as lower alkyl, lower alkoxy, etc.; R 2 is lower alkyl, cyclohexyl or p-substituted phenyl) having an aromatic group at the α-position with a methylating agent such as methyl halide under alkaline reaction condition in the presence of a quaternary ammonium salt in a solvent such as methyl chloride at 10W40°C, preferably 20W30°C. The alkaline reaction condition is preferably achieved by adding an aqueous solution of a caustic alkali to the reaction system. The concentration of the caustic alkali solution is preferably 8W20%, especially 8W 10%. The quaternary ammonium salt acts as a catalyst, and is used at an equimolar amount based on the raw material. n COPYRIGHT: (C)1984,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-970042541-A |
| priorityDate | 1982-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.