http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5946226-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d75d1a4caed60a9316608ed9c231546c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1982-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf1759b3d41c2539e10a0798d9537db7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e950b9d34060d7509513746c3ab748b |
| publicationDate | 1984-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5946226-A |
| titleOfInvention | Novel phospholipid a containing choline and carcinostatic agent containing the same |
| abstract | NEW MATERIAL:The phospholipid A contg. choline having the following characteristics: colorless oily substance; molecular weight, 805 and 831 by FD-MS and SIMS; soluble in ether, methanol, etc., insoluble in acetone and water; positive to Dragendorff reagent, Dittmer-Lester reagent, etc.; negative to H 2 SO 4 , ninhydrin reagent, etc. n USE: Carcinostatic agent. n PROCESS: The embryo of a rainbow trout (salma gairdneri) of 12W14 days after fertilization is homogenized, and extracted successively with acetone, ether, and a chloroform-methanol mixture. The extracts are mixed to together, concentrated in vacuum, and developed by silica gel column chromatography. The active component existing in the chloroform-methanol fraction is purified to obtain the phospholipid A. The objective drug having excellent carcinostatic activity and low toxicity can be obtained by using the phospholipid A as an active component. Dose: 0.01W100mg/kg daily for oral administration and ≤ about 10mg/kg daily for parenteral administration. n COPYRIGHT: (C)1984,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0211516-A |
| priorityDate | 1982-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.