| abstract |
PURPOSE: To prepare the titled substance useful as an intermediate of carcinostatic agent, antiviral agent, or a remedy for keratitis and herpes, etc., easily, by reacting α-trifluoromethylacrylic acid or its acid halide with a urea derivative. n CONSTITUTION: The compound of formula III is prepared by reacting the compound of formula I (X is OH or halogen) with the compound of formula II(R 1 and R 2 are H, alkyl or aromatic group; y is O or S) preferably in an aprotic polar solvent (e.g. DMF). When X is OH, it is preferable to obtain the objective compound either by mixing the above raw materials in a solvent, heating the mixture at 80W100°C and treating the resultant addition product with a condensation agent (e.g. dicyclohexylcarbodiimide), or by reacting the raw materials in the presence of a condensation agent at -10W+50°C. n COPYRIGHT: (C)1984,JPO&Japio |