| abstract |
PURPOSE:The titled external member, prepared by laminating a base layer obtained by incorporating a pressure-sensitive adhesive layer having the adhesive property at ordinary temperature with nifedipine on a support layer capable of shielding light within a specific wavelength range, useful for treating angina pectoris, etc., and having improved lasting property and stability. CONSTITUTION:An external member for medical use prepared by laminating a base layer containing a chemical, and obtained by incorporating a pressure-sensitive adhesive layer having the adhesive property at ordinary temperature, e.g. ethyl (meth)acrylate, with nifedipine on a support capable of shielding light having <=500nm wavelength. The nifedipine is relatively stable to temperature and humidity but very unstable to light. The change of the oral administration of the nifedipine into the percutaneous administration improves the lasting property, and the use of one kind selected from a composite material of a plastic with a metallic thin film, e.g. Al, a plastic film containing a light-shielding powder or a colored plastic film as the support prevents the photolysis of the nifedipine. |