| abstract |
NEW MATERIAL:The compound of formula I [R is H, phenyl(lower alkyl), benzoyl (lower alkyl), benzoyl, phenyl(lower alkenylcarbonyl), etc.] and its salt. n EXAMPLE: 4-(4-Benzyl-1-piperazinyl)carbostyryl monohydrochloride. n USE: A cardiac useful as a remedy of various cardiac diseases such as congestive failure, mitral incompetence, atrial fibrillation, atrial flutter, etc. n PROCESS: The compound of formula I can be prepared, e.g. by reacting the compound of formula II with the piperazine derivative of formula III in a conventional inert solvent or in the absence of solvent, at room temperature W150°C for 1W30hr preferably using a basic compound as an acid acceptor. n COPYRIGHT: (C)1984,JPO&Japio |