| abstract |
PURPOSE: To provide an indometacin-contg. adhesive tape excellent in percutaneous absorption and therapeutic effect and well suited to occlusive dressing for inflammatory diseases, by forming a press.-sensitive adhesive layer contg. indometacin and a penetration assistant on impermeable films. n CONSTITUTION: Indometacin and penetration assistants (e.g., glycyrrhetic acid) are mixed with a soln. of binders such as acrylate/acrylic acid copolymers or acrylate/vinyl acetate copolymers. Said mixed soln. is applied onto inpermeable films (e.g., polyethylene films, polyvinyl chloride films, polyvinyliden chloride films) to yield the intended indometacin-contg. adhesive tape. The proper amt. of indometacin or penetration assistants to be contained is about 60W400μg/cm 2 or 5W100μg/cm 2 , respectively. Said tape is used by directly applying to inflamed skin. n COPYRIGHT: (C)1984,JPO&Japio |