http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5927869-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b9822bceff022feda91b10019125e70f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 |
| filingDate | 1982-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b466a633772259ebd6ee737b1d55300 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_202d48f90d70811a7f24b245aac00325 |
| publicationDate | 1984-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5927869-A |
| titleOfInvention | Preparation of 4-oxo-4,5,6,7-tetrahydroindole |
| abstract | PURPOSE: To prepare the titled compound useful as a precursor for the synthesis of an antiarrhythmic agent, pindolol, in high efficiency, by using easily available inexpensive 4-oxo-4,5,6,7-tetrahydrobenzofuran as a raw material, and reacting the material with ammonia. n CONSTITUTION: The objective compound of formula III is prepared by (1) reacting chloroacetaldehyde with 1,3-cyclohexanedione of formula I in the presence of a base such as NaHCO 3 , pyridine, etc. in a reaction liquid of 4W10pH, at -10°CW near the room temperature, if necessary adding a binary-phase solvent such as water and ethyl acetate, etc. to the reaction system, (2) treating the reaction product with an acid to obtain the 4-oxo-4,5,6,7-tetrahydrobenzofuran of formula II (R and R' are H or alkyl), and (3) reacting the compound with ammonia and water in a solvent such as ethanol at 130W170°C. n USE: Synthetic intermediate of 4-substituted indole-based pharamaceuticals., etc. n COPYRIGHT: (C)1984,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S60228456-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S60228455-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S61180767-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0411540-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0262549-B2 |
| priorityDate | 1982-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.