| abstract |
NEW MATERIAL:The compound of formula I [R 1 WR 4 are H, (substituted) alkyl, etc.; R 5 is (substituted) cycloalkyl, acyl or heterocyclic group; A is bond, (substituted) alkylene, alkenylene, etc.; n is 1W3] and its salt. n EXAMPLE: DL-2-( β-2-Furylacrylamide )-N 5 -methyl-N 1 ,N 1 -di-n-propylpentane-1,5-diamide. n USE: An antiulcer agent. n PREPARATION: The compound of formula I can be prepared by reacting the compound of formula II or its salt with the compound of formula R 5 -A-COOH or its reactive derivative at the carboxyl group. As an alternative method, the reaction of the compound of formula III or its reactive derivative at the carboxyl group with the amine of formula IV gives the compound of formula I . n COPYRIGHT: (C)1984,JPO&Japio |