| abstract |
PURPOSE: To prepare the titled substance useful as an intermediate of thienamycin, by reacting the corresponding 4-hydroxyethyl-2-azetidinone compound with pyridinium dichromate or a complex of pyridine and chromic anhydride. n CONSTITUTION: The compound of formula III can be prepared in one step, by reacting the compound of formula I [R is H or amino-protecting group; E is H, azido, amino, alkyl, R 1 -CO-, group of formula II, or R 5 NH- (R 1 WR 3 are H or alkyl); R 4 is H or OH-protecting group; R 5 is partial structure of the acyl side chain of a β-lactam antibiotic substance, or amino-protecting group] with pyridinium dichromate or a complex of pyridine and chromic anhydride. The reaction is carried out in a solvent such as DMF, dimethylacetamide, methylene chloride, etc. n COPYRIGHT: (C)1984,JPO&Japio |